Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation

8 Apr 2022

Abstract excerpt

Women with autoimmune and inflammatory aetiologies can exhibit reduced fecundity. TNFAIP3 is a master negative regulator of inflammation, and has been linked to many inflammatory conditions by genome wide associations studies, however its role in fertility remains unknown. Here we show that mice harbouring a mild Tnfaip3 reduction-of-function coding variant (Tnfaip3I325N) that reduces the threshold for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Reproductive System and Pregnancy
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35464428
DOI: 10.3389/fimmu.2022.811525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS InflammationPMID 35464428Read ↗

Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in non-human primateSemantic proximity Read ↗

Genetic Mutations Associated With TNFAIP3 (A20) Haploinsufficiency and Their Impact on Inflammatory Diseases.Semantic proximity Read ↗

Protective Effect of TNFAIP3 on Testosterone Production in Leydig Cells under an Aging Inflammatory MicroenvironmentSemantic proximity Read ↗

The Inflammasome in Reproductive Biology: A Promising Target for Novel TherapiesSemantic proximity Read ↗

Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases.Semantic proximity Read ↗

NLRP2 controls age-associated maternal fertilitySemantic proximity Read ↗

Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's diseaseSemantic proximity Read ↗

Systems Genetics Cytokine Screen Identifies T cells as Necessary for Letrozole-Induced LH Elevation in a PMOS-like Mouse ModelSemantic proximity Read ↗

Genetic insights into the immunological basis of male infertility: a translational perspective.Semantic proximity Read ↗

Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive HealthSemantic proximity Read ↗

The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanismsSemantic proximity Read ↗

Dysregulation of follicle development in a mouse model of premature ovarian insufficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.