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Article

Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.

Gut microbes - 2 Jan 2017

Jacobs Jonathan P, Lin Lin, Goudarzi Maryam, Ruegger Paul, McGovern Dermot P B, Fornace Albert J, Borneman James, Xia Lijun, Braun Jonathan

Abstract excerpt

Intestinal dysbiosis is thought to confer susceptibility to inflammatory bowel disease (IBD), but it is unknown whether dynamic changes in the microbiome contribute to fluctuations in disease activity. We explored this question using mice with intestine-specific deletion of C1galt1 (also known as T-synthase) (Tsyn mice). These mice develop spontaneous microbiota-dependent colitis with a remitting/relapsing course...

Topics

Animals
Bacteria
Cohort Studies
Colitis
Colon
Crohn Disease
Disease Models, Animal
Galactosyltransferases
Gastrointestinal Microbiome
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mucins

Polymorphism, Single Nucleotide

T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 27874308
DOI: 10.1080/19490976.2016.1257469
PMCID: PMC5341916

Genes

CD4
IL17A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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