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Article

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.

The Journal of clinical investigation - 1 Apr 2011

Fu Jianxin, Wei Bo, Wen Tao, Johansson Malin E V, Liu Xiaowei, Bradford Emily, Thomsson Kristina A, McGee Samuel, Mansour Lilah, Tong Maomeng, McDaniel J Michael, Sferra Thomas J, Turner Jerrold R, Chen Hong, Hansson Gunnar C, Braun Jonathan, Xia Lijun

Abstract excerpt

Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer overlying the gut epithelium. Impaired expression of intestinal O-glycans has been observed in patients with ulcerative colitis (UC), but its role in the etiology of this disease is unknown. Here, we report that mice with intestinal epithelial cell-specific deficiency of core 1-derived...

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Identifiers

PMID: 21383503
DOI: 10.1172/JCI45538
PMCID: PMC3069788

Genes

C1GALT1C1
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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