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The microbiome determines the phenotype in CTLA-4 insufficient mice and men

2026-08-17

Abstract excerpt

CTLA-4 (haplo)insufficiency displays incomplete penetrance and phenotypic heterogeneity, indicating the involvement of additional disease modifiers beyond the genetic defect. Microbiome analyses reveal a positive association between disease severity and intestinal dysbiosis, highlighting the microbiome as a critical contributor. To investigate this relationship mechanistically, we generated Ctla4⁺ / ⁻ wildlings...

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Literature Corpus work
850100da-a944-52c2-a993-e1468e289757
DOI
10.64898/2026.08.14.742114
Open publication

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The microbiome determines the phenotype in CTLA-4 insufficient mice and menDOI 10.64898/2026.08.14.742114
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