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Article

Loss of intestinal O-glycans promotes spontaneous duodenal tumors.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2016

Gao Nan, Bergstrom Kirk, Fu Jianxin, Xie Biao, Chen Weichang, Xia Lijun

Abstract excerpt

Mucin-type O-glycans, primarily core 1- and core 3-derived O-glycans, are the major mucus barrier components throughout the gastrointestinal tract. Previous reports identified the biological role of O-glycans in the stomach and colon. However, the biological function of O-glycans in the small intestine remains unknown. Using mice lacking intestinal core 1- and core 3-derived O-glycans [intestinal epithelial cell...

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Identifiers

PMID: 27229122
DOI: 10.1152/ajpgi.00060.2016
PMCID: PMC4967177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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