Article
Loss of intestinal O-glycans promotes spontaneous duodenal tumors.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2016
Gao Nan, Bergstrom Kirk, Fu Jianxin, Xie Biao, Chen Weichang, Xia Lijun
Abstract excerpt
Mucin-type O-glycans, primarily core 1- and core 3-derived O-glycans, are the major mucus barrier components throughout the gastrointestinal tract. Previous reports identified the biological role of O-glycans in the stomach and colon. However, the biological function of O-glycans in the small intestine remains unknown. Using mice lacking intestinal core 1- and core 3-derived O-glycans [intestinal epithelial cell...
Topics
- Adenocarcinoma
- Animals
- Cell Line
- Cell Proliferation
- Cell Transformation, Neoplastic
- Duodenal Neoplasms
- Duodenitis
- Duodenum
- Galactosyltransferases
- Genetic Predisposition to Disease
- Glycosylation
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mice, Knockout