Article
Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016
Kudelka Matthew R, Hinrichs Benjamin H, Darby Trevor, Moreno Carlos S, Nishio Hikaru, Cutler Christopher E, Wang Jianmei, Wu Huixia, Zeng Junwei, Wang Yingchun, Ju Tongzhong, Stowell Sean R, Nusrat Asma, Jones Rheinallt M, Neish Andrew S, Cummings Richard D
Abstract excerpt
Inflammatory bowel disease (IBD) results from aberrant immune stimulation against a dysbiotic mucosal but relatively preserved luminal microbiota and preferentially affects males in early onset disease. However, factors contributing to sex-specific risk and the pattern of dysbiosis are largely unexplored. Core 1 β3GalT-specific molecular chaperone (Cosmc), which encodes an X-linked chaperone important for...
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