Article
Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma.
PloS one - 13 Jan 2011
Lee Seong Jin, Lee Min Hee, Kim Dong Wook, Lee Seongeun, Huang Songmei, Ryu Min Jeong, Kim Yong Kyung, Kim Sung Jin, Kim Soung Jung, Hwang Jung Hwan, Oh Sangphil, Cho Heeyeong, Kim Jin Man, Lim Dae-Sik, Jo Young Suk, Shong Minho
Abstract excerpt
BACKGROUND: The BRAF(V600E) mutation leading to constitutive signaling of MEK-ERK pathways causes papillary thyroid cancer (PTC). Ras association domain family 1A (RASSF1A), which is an important regulator of MST1 tumor suppressor pathways, is inactivated by hypermethylation of its promoter region in 20 to 32% of PTC. However, in PTC without RASSF1A methylation, the regulatory mechanisms of RASSF1A-MST1 pathways...
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