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Article

BRAF-activated WT1 contributes to cancer growth and regulates autophagy and apoptosis in papillary thyroid carcinoma.

Journal of translational medicine - 5 Feb 2022

Chen Xing, Lin Shan, Lin Ying, Wu Songsong, Zhuo Minling, Zhang Ailong, Zheng Junjie, You Zhenhui

Abstract excerpt

BACKGROUND: Papillary thyroid carcinoma (PTC) is one of most prevalent malignant endocrine neoplasms, and it is associated with a high frequency of BRAF gene mutations, which lead to lymphatic metastasis and distant metastasis that promote tumor progression. The molecular mechanism of PTC and the role of BRAF mutation in PTC progression and development need to be further elucidated. METHODS: In this study, a...

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Identifiers

PMID: 35123502
DOI: 10.1186/s12967-022-03260-7
PMCID: PMC8818187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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