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Establishment and characterization of NCC-GCTB16-C1: novel patient-derived cell line of giant cell tumor of bone.

Human cell - 9 Mar 2026

Kono Kenta, Shiota Yomogi, Osaki Julia, Shu Ting-Ting, Kamio Satoshi, Iwata Shintaro, Nishino Shogo, Yoshida Akihiko, Ohtsuki Sumio, Ohtori Seiji, Kawai Akira, Kondo Tadashi

Abstract excerpt

Giant cell tumor of bone (GCTB) is a locally aggressive osteolytic bone tumor characterized by recurrent mutation in the H3-3A gene. Although surgical resection remains the mainstay of treatment, a considerable proportion of patients experience local recurrence or pulmonary metastasis, and effective systemic therapy has not yet been established. Given the inherent clinicopathological heterogeneity of GCTB, we...

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PMID: 41801630
DOI: 10.1007/s13577-026-01363-7

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