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Article

Testosterone Rescues the De-Differentiation of Smooth Muscle Cells Through Serum Response Factor/Myocardin.

Journal of cellular physiology - 1 Oct 2017

Leimgruber Carolina, Quintar Amado A, Peinetti Nahuel, Scalerandi María V, Nicola Juan P, Miano Joseph M, Maldonado Cristina A

Abstract excerpt

Prostatic smooth muscle cells (pSMCs) differentiation is a key factor for prostatic homeostasis, with androgens exerting multiple effects on these cells. Here, we demonstrated that the myodifferentiator complex Srf/Myocd is up-regulated by testosterone in a dose-dependent manner in primary cultures of rat pSMCs, which was associated to the increase in Acta2, Cnn1, and Lmod1 expressions. Blocking Srf or Myocd by...

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Identifiers

PMID: 27861881
DOI: 10.1002/jcp.25679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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