[Testosterone suppresses oxidized low-density lipoprotein-induced vascular smooth muscle cell phenotypic transition and proliferation].

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Article

[Testosterone suppresses oxidized low-density lipoprotein-induced vascular smooth muscle cell phenotypic transition and proliferation].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Jun 2015

Zhou Wei, Liu Wei, Liao Hua, Cao Zhe, Xie Han, Zhang Shaoying, Chen Manhua

Abstract excerpt

OBJECTIVE: To investigate the inhibitory effect of testosterone on oxidized low-density lipoproteins (ox-LDL)-stimulated phenotypic transition and proliferation of vascular smooth muscle cells (VSMCs) in vitro, and explore its possible mechanisms. METHODS: Rat VSMCs were cultured using serum starvation method to make cell synchronization. Cells in vitro were divided into control group, ox-LDL group (treated with...

Topics

Actins
Animals
Cell Cycle
Cell Proliferation
Dose-Response Relationship, Drug
GTP Phosphohydrolases
Gene Expression Regulation
Lipoproteins, LDL
Membrane Proteins
Mitochondrial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinase 1

Mitogen-Activated Protein Kinase 3

Muscle, Smooth, Vascular

Osteopontin

Phenotype

Proliferating Cell Nuclear Antigen

Rats

Testosterone

Source

Open in PubMed

Identifiers

PMID: 26062420

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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