Article
Both nongenomic and genomic effects are involved in estradiol's enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells.
The Prostate - 15 Feb 2010
Zhang Zhisong, Wang Liang, Mei Mei, Zhu Yan, Du Xiaoling, Lee Chung, Park Irwin, Zhang Ju, Shi Jiandang
Abstract excerpt
BACKGROUND: Stromal smooth muscle cells (SMCs) play an important role in the pathogenesis and clinical symptom of benign prostatic hyperplasia. We had reported that estrogen enhances the phenotype of SMC in cultured prostate stromal cells (PRSCs). Here we further investigate the mechanism by which estrogen affects the differentiation of PRSCs. METHODS: Primary cultured PRSCs were stimulated with E2 or BSA-E2. The...
Topics
- Antibodies, Neutralizing
- Cell Differentiation
- Cells, Cultured
- Drug Synergism
- Estradiol
- Estrogen Antagonists
- Flavonoids
- Fulvestrant
- Gene Expression Regulation
- Genome, Human
- Humans
- MAP Kinase Signaling System
- Male