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Article

The platelet-derived growth factor receptor/STAT3 signaling pathway regulates the phenotypic transition of corpus cavernosum smooth muscle in rats.

PloS one - 1 Jan 2017

Yan Jun-Feng, Huang Wen-Jie, Zhao Jian-Feng, Fu Hui-Ying, Zhang Gao-Yue, Huang Xiao-Jun, Lv Bo-Dong

Abstract excerpt

Erectile dysfunction (ED) is a common clinical disease that is difficult to treat. We previously found that hypoxia modulates the phenotype of primary corpus cavernosum smooth muscle cells (CCSMCs) in rats, but the underlying molecular mechanism is still unknown. Platelet-derived growth factor receptor (PDGFR)-related signaling pathways are correlated with cell phenotypic transition, but research has been focused...

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Becaplermin
Cell Hypoxia
Erectile Dysfunction
Muscle, Smooth
Penis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-sis

Receptors, Platelet-Derived Growth Factor

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Open in PubMed Open full text

Identifiers

PMID: 28245285
DOI: 10.1371/journal.pone.0172191
PMCID: PMC5330473

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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