Article
Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2010
Toporsian Mourad, Jerkic Mirjana, Zhou Yu-Qing, Kabir Mohammed G, Yu Lisa X, McIntyre Brendan A S, Davis Adrienne, Wang Yu Jing, Stewart Duncan J, Belik Jaques, Husain Mansoor, Henkelman Mark, Letarte Michelle
Abstract excerpt
OBJECTIVE: Loss-of-function mutations in genes coding for transforming growth factor-beta/bone morphogenetic protein receptors and changes in nitric oxide(*) (NO(*)) bioavailability are associated with hereditary hemorrhagic telangiectasia and some forms of pulmonary arterial hypertension. How th...
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