Article
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
Human molecular genetics - 15 Sept 2006
Ehrnhoefer Dagmar E, Duennwald Martin, Markovic Phoebe, Wacker Jennifer L, Engemann Sabine, Roark Margaret, Legleiter Justin, Marsh J Lawrence, Thompson Leslie M, Lindquist Susan, Muchowski Paul J, Wanker Erich E
Abstract excerpt
Huntington's disease (HD) is a progressive neurodegenerative disorder for which only symptomatic treatments of limited effectiveness are available. Preventing early misfolding steps and thereby aggregation of the polyglutamine (polyQ)-containing protein huntingtin (htt) in neurons of patients may represent an attractive therapeutic strategy to postpone the onset and progression of HD. Here, we demonstrate that...
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