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Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.

Human molecular genetics - 15 Sept 2006

Ehrnhoefer Dagmar E, Duennwald Martin, Markovic Phoebe, Wacker Jennifer L, Engemann Sabine, Roark Margaret, Legleiter Justin, Marsh J Lawrence, Thompson Leslie M, Lindquist Susan, Muchowski Paul J, Wanker Erich E

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative disorder for which only symptomatic treatments of limited effectiveness are available. Preventing early misfolding steps and thereby aggregation of the polyglutamine (polyQ)-containing protein huntingtin (htt) in neurons of patients may...

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Identifiers

PMID: 16893904
DOI: 10.1093/hmg/ddl210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16893904-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.PMID 16893904Read ↗

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