ABCC2 (1249G > A) polymorphism implicates altered transport activity for sorafenib.

doi:10.1080/00498254.2016.1262976

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Article

ABCC2 (1249G > A) polymorphism implicates altered transport activity for sorafenib.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Nov 2017

Wei Danyun, Zhang Hong, Peng Rui, Huang Cuiyuan, Bai Ruidan

Abstract excerpt

1. Multidrug resistance-associated protein 2 (MRP2), encoded by the ABCC2 gene, is an efflux transporter of several endogenous substrates and xenobiotics. Here, we investigated whether the 1249G > A (rs2273697) polymorphism in ABCC2 affects the ability of MRP2 to pump the multi-tumor drug sorafenib out of cells. 2. Human embryonic kidney 293 (HEK 293) cell lines transfected with ABCC2-1249G and ABCC2-1249A were...

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PMID: 27855531
DOI: 10.1080/00498254.2016.1262976

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ABCC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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