Article
Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2005
Bosch Tessa M, Kjellberg Linda M, Bouwers Anja, Koeleman Bobby P C, Schellens Jan H M, Beijnen Jos H, Smits Paul H M, Meijerman Irma
Abstract excerpt
BACKGROUND: ABCG2 is a drug transporter involved in the protection of tissues by actively transporting toxic substances and xenobiotics out of cells. Cancer cells overexpressing the ABCG2 gene show multidrug resistance to mitoxantrone-, methotrexate-, doxorubicin-, and camptothecin-based anticancer drugs, such as topotecan and SN-38. Large interindividual differences have been shown in oral availability and...
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