Article
HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy.
Journal of the American Society of Nephrology : JASN - 1 May 2017
Le Wei-Bo, Shi Jing-Song, Zhang Tao, Liu Lei, Qin Hua-Zhang, Liang ShaoShan, Zhang Yuan-Wei, Zheng Cun-Xia, Jiang Song, Qin Wei-Song, Zhang Hai-Tao, Liu Zhi-Hong
Abstract excerpt
Idiopathic membranous nephropathy (MN) is associated with HLA; however, the HLA allele involved remains unknown. To identify the HLA risk alleles associated with phospholipase A2 receptor (PLA2R)-related MN in the Chinese population, we sequenced the entire MHC region in DNA samples from 99 patients with PLA2R-related MN, 50 patients with PLA2R-unrelated MN, and 100 healthy subjects. Two HLA risk alleles,...
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