Article
Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ.
Oncogene - 22 Jun 2017
Escoll M, Gargini R, Cuadrado A, Anton I M, Wandosell F
Abstract excerpt
Wild-type p53 (wtp53) is described as a tumour suppressor gene; mutations in this gene occur in many human cancers and promote oncogenic capacity. Here, we establish that the oncogenic activity of mutant p53 (mtp53) is driven by the WASP-interacting protein (WIP). WIP knockdown from mtp53-expressing glioblastoma and breast cancer cells (BCC) greatly reduced proliferation and growth capacity of cancer stem cell...
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