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Article

WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion

24 Mar 2016

Abstract excerpt

Cancer cells form actin-rich degradative protrusions (invasive pseudopods and invadopodia), which allows their efficient dispersal during metastasis. Using biochemical and advanced imaging approaches, we demonstrate that the N-WASP-interactors WIP and WICH/WIRE play non-redundant roles in cancer cell invasion. WIP interacts with N-WASP and cortactin and is essential for invadopodium assembly, whereas WICH/WIRE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27009365
DOI: 10.1038/srep23590

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WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasionPMID 27009365Read ↗

WIP is necessary for matrix invasion by breast cancer cellsSemantic proximity Read ↗

WIP Provides an Essential Link between Nck and N-WASP during Arp2/3-Dependent Actin PolymerizationSemantic proximity Read ↗

The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms.Semantic proximity Read ↗

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WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth.Semantic proximity Read ↗

WASP and WAVE family proteins: Friends or foes in cancer invasion?Semantic proximity Read ↗

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeletonSemantic proximity Read ↗

A cancer cell metalloprotease triad regulates the basement membrane transmigration program.Semantic proximity Read ↗

Toca-1 Mediates Cdc42-Dependent Actin Nucleation by Activating the N-WASP-WIP ComplexSemantic proximity Read ↗

LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasionSemantic proximity Read ↗

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B CellsSemantic proximity Read ↗

Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturationSemantic proximity Read ↗

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