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Article

Investigation of gene-gene interactions in cardiac traits and serum fatty acid levels in the LURIC Health Study.

PloS one - 1 Jan 2020

Zhou Jiayan, Passero Kristin, Palmiero Nicole E, Müller-Myhsok Bertram, Kleber Marcus E, Maerz Winfried, Hall Molly A

Abstract excerpt

Epistasis analysis elucidates the effects of gene-gene interactions (G×G) between multiple loci for complex traits. However, the large computational demands and the high multiple testing burden impede their discoveries. Here, we illustrate the utilization of two methods, main effect filtering based on individual GWAS results and biological knowledge-based modeling through Biofilter software, to reduce the number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32915819
DOI: 10.1371/journal.pone.0238304
PMCID: PMC7485803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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