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Article

Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ.

Scientific reports - 15 Nov 2016

Honma Hajime, Niikura Mamoru, Kobayashi Fumie, Horii Toshihiro, Mita Toshihiro, Endo Hiroyoshi, Hirai Makoto

Abstract excerpt

In this study, we investigated the mutation tendency of a mutator rodent malaria parasite, Plasmodium berghei, with proofreading-deficient DNA polymerase δ. Wild-type and mutator parasites were maintained in mice for over 24 weeks, and the genome-wide accumulated mutations were determined by high-throughput sequencing. The mutator P. berghei had a significant preference for C/G to A/T substitutions; thus, its...

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Identifiers

PMID: 27845384
DOI: 10.1038/srep36971
PMCID: PMC5109483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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