Article
Extreme mutation bias and high AT content in Plasmodium falciparum.
Nucleic acids research - 28 Feb 2017
Hamilton William L, Claessens Antoine, Otto Thomas D, Kekre Mihir, Fairhurst Rick M, Rayner Julian C, Kwiatkowski Dominic
Abstract excerpt
For reasons that remain unknown, the Plasmodium falciparum genome has an exceptionally high AT content compared to other Plasmodium species and eukaryotes in general - nearly 80% in coding regions and approaching 90% in non-coding regions. Here, we examine how this phenomenon relates to genome-wide patterns of de novo mutation. Mutation accumulation experiments were performed by sequential cloning of six P....
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