Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia.

doi:10.1093/hmg/ddn130

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Article

Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia.

Human molecular genetics - 1 Aug 2008

Weickert Cynthia Shannon, Miranda-Angulo Ana L, Wong Jenny, Perlman William R, Ward Sarah E, Radhakrishna Vakkalanka, Straub Richard E, Weinberger Daniel R, Kleinman Joel E

Abstract excerpt

Estrogen modifies human emotion and cognition and impacts symptoms of schizophrenia. We hypothesized that the variation in the estrogen receptor alpha (ESR1) gene and cortical ESR1 mRNA is associated with schizophrenia. In a small case-control genetic association analysis of postmortem brain tissue, genotype CC (rs2234693) and haplotypes containing the C allele of a single-nucleotide polymorphism (SNP) in intron1...

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Identifiers

PMID: 18424448
DOI: 10.1093/hmg/ddn130
PMCID: PMC2465798

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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