Article

17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats

2025-02-11

Abstract excerpt

Low 17β-estradiol (E2) in females of reproductive age, and marked E2 decline with menopause, contributes to heightened symptom severity in schizophrenia (i.e. cognitive dysfunction) and diminished response to antipsychotic medications. However, the underlying mechanisms are unknown. N -methyl-D-aspartate receptor (NMDAR) hypofunction contributes to the pathophysiology of schizophrenia, yet impact of E2 depletion...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 914397b4-cecd-535c-a271-1b93ef34d369
DOI: 10.1101/2025.02.10.637465

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

17β-estradiol status alters NMDAR function and antipsychotic-like activity in female ratsDOI 10.1101/2025.02.10.637465Read

Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunctionSemantic proximity Read

Estrogen actions in the nervous systemSemantic proximity Read

Supraphysiologic doses of 17β-Estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolismSemantic proximity Read

Raloxifene increases prefrontal activity during emotional inhibition in schizophrenia based on estrogen receptor genotype.Semantic proximity Read

Progesterone reduces hyperactivity of female and male dopamine transporter knockout mice.Semantic proximity Read

Estrogen receptor alpha gene polymorphism in schizophrenia: frequency, age at onset, symptomatology and prognosis.Semantic proximity Read

Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors.Semantic proximity Read

Neurobiological aspects of psychosis and gender.Semantic proximity Read

Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia.Semantic proximity Read

A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.Semantic proximity Read

Pharmacogenetic study of the effects of raloxifene on negative symptoms of postmenopausal women with schizophrenia: A double-blind, randomized, placebo-controlled trial.Semantic proximity Read

Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults.Semantic proximity Read