Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes.

doi:10.1038/s41467-025-57452-y

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Article

Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes.

Nature communications - 15 Mar 2025

Sevilla-González Magdalena, Smith Kirk, Wang Ningyuan, Jensen Aubrey E, Litkowski Elizabeth M, Kim Hyunkyung, DiCorpo Daniel A, Hsu Sarah, Cui Jinrui, Liu Ching-Ti, Yu Chenglong, McNeil John J, Lacaze Paul, Westerman Kenneth E, Chang Kyong-Mi, Tsao Philip S, Phillips Lawrence S, Goodarzi Mark O, Sladek Rob, Rotter Jerome I, Dupuis Josée, Florez Jose C, Merino Jordi, Meigs James B, Zhou Jin J, Raghavan Sridharan, Udler Miriam S, Manning Alisa K

Abstract excerpt

Elevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clusters with distinct mechanisms contributing to elevated FI levels. Clusters fall into two types: "non-diabetogenic...

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Identifiers

PMID: 40089507
DOI: 10.1038/s41467-025-57452-y
PMCID: PMC11910595

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