Article
Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes.
Diabetes - 1 Dec 2014
Yaghootkar Hanieh, Scott Robert A, White Charles C, Zhang Weihua, Speliotes Elizabeth, Munroe Patricia B, Ehret Georg B, Bis Joshua C, Fox Caroline S, Walker Mark, Borecki Ingrid B, Knowles Joshua W, Yerges-Armstrong Laura, Ohlsson Claes, Perry John R B, Chambers John C, Kooner Jaspal S, Franceschini Nora, Langenberg Claudia, Hivert Marie-France, Dastani Zari, Richards J Brent, Semple Robert K, Frayling Timothy M
Abstract excerpt
The mechanisms that predispose to hypertension, coronary artery disease (CAD), and type 2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in monogenic primary lipodystrophy-a reduction in subcutaneous adipose tissue-it is clear that it is adipose dysfunction that causes severe insulin resistance (IR), hypertension, CAD, and T2D. We aimed to test the hypothesis that common...
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