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Article

Metabolic insights from extreme human insulin resistance phenotypes.

Best practice & research. Clinical endocrinology & metabolism - 1 Apr 2012

Stears Anna, O'Rahilly Stephen, Semple Robert K, Savage David B

Abstract excerpt

As well as improving diagnostic and clinical outcomes for affected patients, understanding the genetic basis of rare human metabolic disorders has resulted in several fundamental biological insights. In some cases understanding extreme phenotypes has also informed thinking about more prevalent metabolic diseases. Insulin resistance underpins the twin epidemics of obesity and type 2 diabetes as well as accounting...

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Identifiers

PMID: 22498245
DOI: 10.1016/j.beem.2011.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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