Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomere Dysfunction Induced Foci (TIF) Analysis

1 Jan 2015

Abstract excerpt

Telomerase maintains telomeric DNA in eukaryotes during early developments, ~90% of cancer cells and some proliferative stem like cells. Telomeric repeats at the end of chromosomes are associated with the shelterin complex. This complex consists of TRF1, TRF2, Rap1, TIN2, TPP1, POT1 which protect DNA from being recognized as DNA double-stranded breaks. Critically short telomeres or impaired shelterin proteins can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microplastics and Plastic Pollution
Share to Telomeres, Telomerase, and Senescence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27500188
DOI: 10.21769/bioprotoc.1656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomere Dysfunction Induced Foci (TIF) AnalysisPMID 27500188Read ↗

A siRNA-based screen for genes involved in chromosome end protection.Semantic proximity Read ↗

Telomere‐associated proteins: cross‐talk between telomere maintenance and telomere‐lengthening mechanismsSemantic proximity Read ↗

Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations.Semantic proximity Read ↗

Emerging roles of telomeric chromatin alterations in cancerSemantic proximity Read ↗

TRF1 and TRF2: pioneering targets in telomere-based cancer therapySemantic proximity Read ↗

Telomeres, chromosome instability and cancerSemantic proximity Read ↗

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage ResponseSemantic proximity Read ↗

Telomere dysfunction and genome instabilitySemantic proximity Read ↗

Loss of Telomere Protection: Consequences and OpportunitiesSemantic proximity Read ↗

Telomere dysfunction, genome instability and cancerSemantic proximity Read ↗

Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork ArrestSemantic proximity Read ↗

Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.