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Article

ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance.

Nucleic acids research - 1 May 2012

McKerlie Megan, Lin Sichun, Zhu Xu-Dong

Abstract excerpt

Ataxia telangiectasia mutated (ATM), a PI-3 kinase essential for maintaining genomic stability, has been shown to regulate TRF1, a negative mediator of telomerase-dependent telomere extension. However, little is known about ATM-mediated TRF1 phosphorylation site(s) in vivo. Here, we report that ATM phosphorylates S367 of TRF1 and that this phosphorylation renders TRF1 free of chromatin. We show that...

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Source

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Identifiers

PMID: 22266654
DOI: 10.1093/nar/gks035
PMCID: PMC3351164

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance.PMID 22266654Read ↗

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