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Article

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

1 Nov 2015

Abstract excerpt

The yeast homologs of the ATM and ATR DNA damage response kinases play key roles in telomerase-mediated telomere maintenance, but the role of ATM/ATR in the mammalian telomerase pathway has been less clear. Here, we demonstrate the requirement for ATM and ATR in the localization of telomerase to telomeres and telomere elongation in immortal human cells. Stalled replication forks increased telomerase recruitment...

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Identifiers

PMID: 26586433
DOI: 10.1016/j.celrep.2015.10.041

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