Article
Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays.
The Journal of molecular diagnostics : JMD - 1 Jan 2017
Kadri Sabah, Long Bradley C, Mujacic Ibro, Zhen Chao J, Wurst Michelle N, Sharma Shruti, McDonald Nadia, Niu Nifang, Benhamed Sonia, Tuteja Jigyasa H, Seiwert Tanguy Y, White Kevin P, McNerney Megan E, Fitzpatrick Carrie, Wang Y Lynn, Furtado Larissa V, Segal Jeremy P
Abstract excerpt
Next-generation sequencing (NGS) genomic oncology profiling assays have emerged as key drivers of personalized cancer care and translational research. However, validation of these assays to meet strict clinical standards has been historically problematic because of both significant assay complexity and a scarcity of optimal validation samples. Herein, we present the clinical validation of 76 genes from a novel...
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