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Validation and benchmarking of targeted panel sequencing for cancer genomic profiling.

American journal of clinical pathology - 2 Nov 2023

Wang Duo, Wang Sizhen, Zhang Yuanfeng, Cheng Xiaolei, Huang Xin, Han Yanxi, Chen Zhaohui, Liu Cong, Li Jinming, Zhang Rui

Abstract excerpt

OBJECTIVES: To validate a large next-generation sequencing (NGS) panel for comprehensive genomic profiling and improve patient access to more effective precision oncology treatment strategies. METHODS: OncoPanScan was designed by targeting 825 cancer-related genes to detect a broad range of genomic alterations. A practical validation strategy was used to evaluate the assay's analytical performance, involving 97...

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PMID: 37477357
DOI: 10.1093/ajcp/aqad078

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