Article
Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors.
Neoplasia (New York, N.Y.) - 1 Apr 2015
Hovelson Daniel H, McDaniel Andrew S, Cani Andi K, Johnson Bryan, Rhodes Kate, Williams Paul D, Bandla Santhoshi, Bien Geoffrey, Choppa Paul, Hyland Fiona, Gottimukkala Rajesh, Liu Guoying, Manivannan Manimozhi, Schageman Jeoffrey, Ballesteros-Villagrana Efren, Grasso Catherine S, Quist Michael J, Yadati Venkata, Amin Anmol, Siddiqui Javed, Betz Bryan L, Knudsen Karen E, Cooney Kathleen A, Feng Felix Y, Roh Michael H, Nelson Peter S, Liu Chia-Jen, Beer David G, Wyngaard Peter, Chinnaiyan Arul M, Sadis Seth, Rhodes Daniel R, Tomlins Scott A
Abstract excerpt
Next-generation sequencing (NGS) has enabled genome-wide personalized oncology efforts at centers and companies with the specialty expertise and infrastructure required to identify and prioritize actionable variants. Such approaches are not scalable, preventing widespread adoption. Likewise, most targeted NGS approaches fail to assess key relevant genomic alteration classes. To address these challenges, we...
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