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Article

Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing.

PloS one - 1 Jan 2016

Hiemenz Matthew C, Kadauke Stephan, Lieberman David B, Roth David B, Zhao Jianhua, Watt Christopher D, Daber Robert D, Morrissette Jennifer J D

Abstract excerpt

Next-generation sequencing (NGS) is a powerful platform for identifying cancer mutations. Routine clinical adoption of NGS requires optimized quality control metrics to ensure accurate results. To assess the robustness of our clinical NGS pipeline, we analyzed the results of 304 solid tumor and hematologic malignancy specimens tested simultaneously by NGS and one or more targeted single-gene tests (EGFR, KRAS,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27043212
DOI: 10.1371/journal.pone.0152851
PMCID: PMC4820127

Genes

FLT3
BRAF
EGFR
JAK2
KRAS
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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