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Multicenter In-House Evaluation of an Amplicon-Based Next-Generation Sequencing Panel for Comprehensive Molecular Profiling.

Molecular diagnosis & therapy - 1 Mar 2025

Jantus-Lewintre Eloisa, Rappa Alessandra, Ruano Dina, van Egmond Demi, Gallach Sandra, Gozuyasli Dilce, Durães Cecília, Costa José Luis, Camps Carlos, Lacroix Ludovic, Kashofer Karl, van Wezel Tom, Barberis Massimo

Abstract excerpt

BACKGROUND: Predicting response to targeted cancer therapies increasingly relies on both simple and complex genetic biomarkers. Comprehensive genomic profiling using high-throughput assays must be evaluated for reproducibility and accuracy compared with existing methods. METHODS: This study is a multicenter evaluation of the Oncomine™ Comprehensive Assay Plus (OCA Plus) Pan-Cancer Research Panel for comprehensive...

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Identifiers

PMID: 39798063
DOI: 10.1007/s40291-024-00766-2
PMCID: PMC11860996

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