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Article

Senescent stromal cell-induced divergence and therapeutic resistance in T cell acute lymphoblastic leukemia/lymphoma.

Oncotarget - 13 Dec 2016

Habiel David M, Krepostman Nicolas, Lilly Michael, Cavassani Karen, Coelho Ana Lucia, Shibata Takehiko, Elenitoba-Johnson Kojo, Hogaboam Cory M

Abstract excerpt

T cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL/LBL) is a precursor T cell leukemia/lymphoma that represents approximately 15% of all childhood and 25% of adult acute lymphoblastic leukemia. Although a high cure rate is observed in children, therapy resistance is often observed in adults and mechanisms leading to this resistance remain elusive. Utilizing public gene expression datasets, a fibrotic signature...

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Identifiers

PMID: 27835864
DOI: 10.18632/oncotarget.13158
PMCID: PMC5347785

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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