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Article

Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes

12 Apr 2005

Abstract excerpt

APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with HIV-1 nucleoprotein complexes (NPC). A target sequence located within the 5'-untranslated region of the HIV-1 RNA was identified to be necessary and sufficient for efficient APO3G packaging. Fine mapping revealed a...

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Identifiers

PMID: 15827203
DOI: 10.1128/jvi.79.9.5870-5874.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein ComplexesPMID 15827203Read ↗

Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G PackagingSemantic proximity Read ↗

7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G.Semantic proximity Read ↗

Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursorSemantic proximity Read ↗

Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1Semantic proximity Read ↗

RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.Semantic proximity Read ↗

Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging.Semantic proximity Read ↗

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeuticsSemantic proximity Read ↗

GANP interacts with APOBEC3G and facilitates its encapsidation into the virions to reduce HIV-1 infectivity.Semantic proximity Read ↗

APOBEC3G Incorporation into Human Immunodeficiency Virus Type 1 ParticlesSemantic proximity Read ↗

In cell mutational interference mapping experiment (in cell MIME) identifies the 5' polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging.Semantic proximity Read ↗

Distinct viral determinants for the packaging of human cytidine deaminases APOBEC3G and APOBEC3CSemantic proximity Read ↗

Elements in the 5' Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging.Semantic proximity Read ↗

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