Article
Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus.
Investigative ophthalmology & visual science - 1 Nov 2016
Sardell Rebecca J, Persad Patrice J, Pan Samuel S, Whitehead Patrice, Adams Larry D, Laux Reneé A, Fortun Jorge A, Brantley Milam A, Kovach Jaclyn L, Schwartz Stephen G, Agarwal Anita, Haines Jonathan L, Scott William K, Pericak-Vance Margaret A
Abstract excerpt
PURPOSE: Progression rate of age-related macular degeneration (AMD) varies substantially, yet its association with genetic variation has not been widely examined. METHODS: We tested whether progression rate from intermediate AMD to geographic atrophy (GA) or choroidal neovascularization (CNV) was correlated with genotype at seven single nucleotide polymorphisms (SNPs) in the four genes most strongly associated...
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