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Article

Progression of Age-Related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5) or Chromosome 10 (ARMS2/HTRA1) or Both.

JAMA ophthalmology - 1 Mar 2022

Schmitz-Valckenberg Steffen, Fleckenstein Monika, Zouache Moussa A, Pfau Maximilian, Pappas Christian, Hageman Jill L, Agrón Elvira, Malley Claire, Keenan Tiarnan D L, Chew Emily Y, Hageman Gregory S

Abstract excerpt

IMPORTANCE: Age-related macular degeneration (AMD) is a common cause of irreversible vision loss among individuals older than 50 years. Although considerable advances have been made in our understanding of AMD genetics, the differential effects of major associated loci on disease manifestation and progression may not be well characterized. OBJECTIVE: To elucidate the specific associations of the 2 most common...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35113155
DOI: 10.1001/jamaophthalmol.2021.6072
PMCID: PMC8814975

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