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Rare and Common Genetic Variants, Smoking, and Body Mass Index: Progression and Earlier Age of Developing Advanced Age-Related Macular Degeneration.

Investigative ophthalmology & visual science - 1 Dec 2020

Seddon Johanna M, Widjajahakim Rafael, Rosner Bernard

Abstract excerpt

Purpose: To determine behavioral and genetic factors associated with incidence and age of progression to advanced age-related macular degeneration (AMD), geographic atrophy (GA), and neovascular disease (NV), and to quantify these effects. Methods: Longitudinal analyses were conducted among 5421 eyes with nonadvanced AMD at baseline in 2976 participants in the Age-Related Eye Disease Study (mean age of 68.8...

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Identifiers

PMID: 33369641
DOI: 10.1167/iovs.61.14.32
PMCID: PMC7774056

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