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Article

Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates.

Investigative ophthalmology & visual science - 1 Apr 2015

Seddon Johanna M, Silver Rachel E, Kwong Manlik, Rosner Bernard

Abstract excerpt

PURPOSE: To determine the association between genetic variants and transition to advanced age-related macular degeneration (AMD), and to develop a predictive model and online application to assist in clinical decision making. METHODS: Among 2951 subjects in the Age-Related Eye Disease Study, 834 progressed from no AMD, early AMD, or intermediate AMD to advanced disease. Survival analysis was used to assess which...

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Identifiers

PMID: 25655794
DOI: 10.1167/iovs.14-15841
PMCID: PMC4405097

Genes

ARMS2
CFB
CFH
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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