Article
GCTA: a tool for genome-wide complex trait analysis.
American journal of human genetics - 7 Jan 2011
Yang Jian, Lee S Hong, Goddard Michael E, Visscher Peter M
Abstract excerpt
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly software tool called genome-wide complex trait analysis (GCTA), which was developed based on a method we recently developed to address the "missing heritability" problem. GCTA estimates the variance explained by all the SNPs on a...
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