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A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion

1 Nov 2016

Abstract excerpt

The counterregulatory response to hypoglycemia, which restores normal blood glucose levels to ensure sufficient provision of glucose to the brain, is critical for survival. To discover underlying brain regulatory systems, we performed a genetic screen in recombinant inbred mice for quantitative trait loci (QTL) controlling glucagon secretion in response to neuroglucopenia. We identified a QTL on the distal part...

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PMID: 27829151
DOI: 10.1016/j.celrep.2016.10.041

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