Article
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size.
Genes & development - 15 Jul 2008
Kaplan Daniel D, Zimmermann Gregor, Suyama Kaye, Meyer Tobias, Scott Matthew P
Abstract excerpt
Growth and body size are regulated by the CNS, integrating the genetic developmental program with assessments of an animal's current energy state and environmental conditions. CNS decisions are transmitted to all cells of the animal by insulin/insulin-like signals. The molecular biology of the CNS growth control system has remained, for the most part, elusive. Here we identify NS3, a Drosophila nucleostemin...
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