Article
The Role of TCF7L2 in Regulating Energy Metabolism in Thalamocortical Circuitry and its Broader Impact on Social Behavior
2025-11-14
Abstract excerpt
Psychiatric and metabolic disorders often co-occur. While shared genetic factors and cellular dysfunctions are implicated, the underlying molecular mechanisms remain poorly understood. TCF7L2, a risk gene for type 2 diabetes and autism spectrum disorder, is highly expressed in the thalamus—a brain region extensively interconnected with the cortex, playing a key role in sensory processing, motor control, and behavi...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 84b64bd6-3f94-5970-a420-bbd4325f8a48
- DOI
- 10.1101/2025.11.14.684361