Article
Mosaicism in Human Health and Disease.
Annual review of genetics - 23 Nov 2020
Thorpe Jeremy, Osei-Owusu Ikeoluwa A, Avigdor Bracha Erlanger, Tupler Rossella, Pevsner Jonathan
Abstract excerpt
Mosaicism refers to the occurrence of two or more genomes in an individual derived from a single zygote. Germline mosaicism is a mutation that is limited to the gonads and can be transmitted to offspring. Somatic mosaicism is a postzygotic mutation that occurs in the soma, and it may occur at any developmental stage or in adult tissues. Mosaic variation may be classified in six ways: (a) germline or somatic...
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