Circulating Cell-Free DNA to Determine the Fetal RHD Status in All Three Trimesters of Pregnancy.

doi:10.1097/AOG.0000000000001741

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Circulating Cell-Free DNA to Determine the Fetal RHD Status in All Three Trimesters of Pregnancy.

Obstetrics and gynecology - 1 Dec 2016

Moise Kenneth J, Gandhi Manisha, Boring Noemi H, O'Shaughnessy Richard, Simpson Lynn L, Wolfe Honor M, Baxter Jason K, Polzin William, Eddleman Keith A, Hassan Sonia S, Skupski Daniel W, Ryan Greg, Walker Martin, Lam Garrett, Brown Richard, Skoll M Amanda, Robinson Christopher, Sheikh Asad, Bronsteen Richard, Plante Lauren A, McLennan Graham, Chikova Anna, Paladino Toni

Abstract excerpt

OBJECTIVE: To estimate the accuracy of a new assay to determine the fetal RHD status using circulating cell-free DNA. METHODS: This was a prospective, observational study. Maternal blood samples were collected in each trimester of pregnancy in 520 nonalloimmunized RhD-negative patients. Plasma samples were analyzed for circulating cell-free DNA using the SensiGENE RHD test, which used primers for exons 4 and 7 as...

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PMID: 27824757
DOI: 10.1097/AOG.0000000000001741

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