Article
Fetal RHD genotype detection from circulating cell-free fetal DNA in maternal plasma in non-sensitized RhD negative women.
Prenatal diagnosis - 1 Aug 2011
Bombard Allan T, Akolekar Ranjit, Farkas Daniel H, VanAgtmael Anna L, Aquino Frank, Oeth Paul, Nicolaides Kypros H
Abstract excerpt
OBJECTIVE: To examine the performance of the SensiGene Fetal RHD Genotyping Laboratory Developed Test (RHD Genotyping LDT) using circulating cell-free fetal DNA (ccff DNA) extracted from maternal plasma. METHODS: ccff DNA was extracted from maternal blood from non-sensitized women with singleton pregnancies in two cohorts, one with a serotype reference (11-13 weeks' gestation) and one with the reference source...
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