Article
Circulating cell-free fetal DNA for the detection of RHD status and sex using reflex fetal identifiers.
Prenatal diagnosis - 1 Jan 2013
Moise K J, Boring N H, O'Shaughnessy R, Simpson L L, Wolfe H M, Baxter J K, Polzin W, Eddleman K A, Hassan S S, Skupski D, McLennan G, Paladino T, Oeth P, Bombard A
Abstract excerpt
OBJECTIVE: To determine the sensitivity and specificity of circulating cell-free fetal DNA in determining the fetal RHD status and fetal sex. METHODS: Maternal blood was collected in each trimester of pregnancy from RhD negative nonalloimmunized women. Whole blood was centrifuged, separated into plasma and buffy coat, and frozen at -80°C. DNA analysis was conducted via allele-specific primer extensions for exons...
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